Reversible Posterior Leukoencephalopathy Syndrome Associated with Tacrolimus Therapy

Posterior Reversible Leukoencephalopathy Syndrome Associated with Pazopanib

A 62-year-old female patient with metastatic renal cell carcinoma under third-line treatment with pazopanib for 8 weeks suddenly developed severe headaches, grand mal seizures and paresis of the left arm in combination with gait instability as well as nausea and vomiting during her vacation abroad. The emergency physician measured systolic blood pressure values over 300 mm Hg and suspected a st...

Reversible posterior leukoencephalopathy syndrome caused by tacrolimus: a case report

Objective: Explore the clinical and imaging manifestation in one case of reversible posterior leukoencephalopathy syndrome (RPLS) after treatment with tacrolimus. Methods: The clinical and imaging data of this RPLS patient was retrospectively analyzed. Results: MR imaging showed abnormal signals bilaterally in both hemispheres of the cerebellum, the cortex, and in the subcortical area. Low sign...

Reversible posterior leukoencephalopathy syndrome after carboplatin therapy.

A 53-year-old woman presented in September 2004 with a stage IV adenocarcinoma in the upper lobe of the left lung with pleuropulmonary metastasis. She was treated with cisplatin (70 mg/m 2 on day 1 and gemcitabine 1250 mg/m 2 on days 1 and 8) by intravenous administration every 3 weeks. After five treatment cycles, the administration of cisplatin was stopped because of a low clearance creatinin...

Reversible posterior leukoencephalopathy syndrome.

Reversible Posterior Leukoencephalopathy Syndrome

Hinchey et al used the term „reversible posterior leukoencephalopathy syndrome“ in 1996 to describe a syndrome characterized by headache, confusion, seizures and vision disturbances, including cortical blindness, connected with reversible changes on brain magnetic resonance imaging (MRI) which pointed to the white matter eodema, predominantly in the posterior brain regions (1). Initially, this ...